In an affluent city perched on Ontarios Niagara Escarpment, residents begin turning up on the pathologists autopsy table with what looks like epidemic mad cow disease. Zol Szabo, a public-health doctor and former chef, and Hamish Wakefield, a young infectious-diseases specialist, must trace the epidemic to its source while dodging the deadly prions that appear to have contaminated almost everything in the supermarket.

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